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. Author manuscript; available in PMC: 2013 Sep 15.
Published in final edited form as: Am J Cardiol. 2012 Jun 8;110(6):862–869. doi: 10.1016/j.amjcard.2012.05.015

Table 5.

Multivariate Models for HF-ACTION Cardiovascular Disease Mortality or Heart Failure Hospitalization Endpoint (n=512 with complete data)

Multivariate Model Multivariate Model Chi-Square Value Multivariate p-value of added predictor(s) beyond the basic model C-index
Basic 100.4 0.70
Basic + Left ventricular diastolic dimension 107.1 0.009 0.71
Basic + Left ventricular mass 105.3 0.03 0.70
Basic + Left ventricular ejection fraction 103.8 0.06 0.70
Basic + Left atrial dimension 101.3 0.33 0.70
Basic + Peak mitral early diastolic-to-peak late diastolic velocity ratio 127.4 <0.0001 0.73
Basic + Early diastolic deceleration time 105.6 0.02 0.71
Basic + Peak mitral early diastolic velocity-to-tissue Doppler peak early diastolic myocardial velocity ratio 121.2 <0.0001 0.72
Basic + Mitral regurgitation grade 111.6 0.0008 0.71
Basic + All 8 echo variables 149.5 multiple added predictors 0.74
Basic + Peak oxygen consumption 132.6 <0.0001 0.74
Basic + Peak oxygen consumption + Peak mitral early diastolic-to-peak late diastolic velocity ratio 146.4 0.0002 (E/A) <0.0001 (peak VO2) 0.75

Basic multivariate model for secondary endpoint includes age (truncated at 62 years), body surface area, BUN (truncated at 39mg/dL), gender, KCCQ symptom stability score, loop diuretic dose (truncated at 100mg), race, ventricular conduction.