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. Author manuscript; available in PMC: 2013 Jun 1.

Published in final edited form as: Gene Ther. 2012 Jan 12;19(12):1166–1176. doi: 10.1038/gt.2011.200

Schematic of the gene structures of AAVrh10 vectors. The vectors encode A) luciferase, B) human FVIII heavy chain cDNA (base pairs 1-2292), and C) human FVIII light chain cDNA (base pairs 1-57 and 4744-7053). Vector was administration was performed on the second day of life. (CBA=chicken β-actin promoter/CMV enhancer, hgH pA=human growth hormone polyadenylation signal, ITR=AAV inverted terminal repeat, ss=signal sequence. Letters represent domains of the factor VIII cDNA and * indicates incomplete domain.)

Schematic of the gene structures of AAVrh10 vectors. The vectors encode A) luciferase, B) human FVIII heavy chain cDNA (base pairs 1-2292), and C) human FVIII light chain cDNA (base pairs 1-57 and 4744-7053). Vector was administration was performed on the second day of life. (CBA=chicken β-actin promoter/CMV enhancer, hgH pA=human growth hormone polyadenylation signal, ITR=AAV inverted terminal repeat, ss=signal sequence. Letters represent domains of the factor VIII cDNA and * indicates incomplete domain.)