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Humoral immune response to hFVIII in hemophilic mice challenged with hFVIII as adults. At 16 days after alum-hFVIII injection, mice were bled and plasma analyzed for antibodies to hFVIII in both control (saline-injected as neonates) and neonatal AAVrh10-hFVIII-HC+LC-injected mice. (n≥3 animals per group.) (Error bars represent mean + SD)
