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Effects of tolcapone on prefrontal cortex (PFC) extracellular dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in Lenti-CAG-Comt or control Lenti-CAG-GFP mice. Three 20 min baseline fractions were collected before tolcapone (6 and 30 mg kg−1 intraperitoneally (i.p.)) injection and thereafter 20 min fractions were collected for 120 min. Data are means±s.e.m. from three mice.
