Table 2. Significantly different metabolites in schizophrenia and test for neuroleptics influence.
| Metabolites |
Cases versus controls (NF+NT versus controls)a |
NF versus controls | NT versus NF | |
|---|---|---|---|---|
| OR (95%CI) | P-value | P-valueb | P-valueb | |
| Ornithinec | 1.92 (1.53–2.44) | 2.9 × 10−8 | 0.01 | 0.41 |
| Glutaminec | 0.57 (0.46–0.7) | 1.3 × 10−7 | 0.006 | 0.98 |
| Argininec | 0.64 (0.52–0.78) | 9.1 × 10−6 | 0.02 | 0.99 |
| Histidinec | 0.7 (0.58–0.84) | 2.5 × 10−4 | 0.03 | 0.82 |
| PC ae C38:6c | 0.59 (0.46–0.73) | 4.0 × 10−6 | 0.03 | 0.66 |
| PC ae C34:3d | 0.65 (0.52–0.8) | 1.2 × 10−4 | 0.5 | 0.04 |
| C2 | 0.66 (0.53–0.81) | 1.2 × 10−4 | 0.16 | 0.5 |
| Methionine | 0.7 (0.57–0.84) | 3.0 × 10−4 | 0.13 | 0.94 |
| PC ae C36:5 | 0.57 (0.45–0.7) | 7.2 × 10−7 | 0.08 | 0.36 |
| PC ae C42:1 | 1.67 (1.32–2.16) | 4.5 × 10−5 | 0.74 | 0.07 |
| PC ae C38.5 | 0.69 (0.55–0.84) | 4.0 × 10−4 | 0.16 | 0.88 |
| PC aa C38:0 | 0.67 (0.53–0.82) | 2.2 × 10−4 | 0.08 | 0.84 |
Abbreviations: CI, confidence interval; NF, neuroleptics-free cases; NT, neuroleptics-taken cases; OR, odds ratio.
a
Odds ratios (95% confidence intervals) and P-values were calculated from multivariate logistic regression analysis with adjustment for age, sex and BMI (Bonferroni correction P-value <4.8 × 10−4).
b
Tukey's HSD test was applied to test concentration difference between the two groups. P-value <0.05 are shown in bold.
c
No significant neuroleptics influence (that is no significant difference in NT versus NF, but difference in NF versus controls).
d
Potential neuroleptics influence (that is, significant difference in NT versus NF; however, no difference in NF versus controls).