Table 2. Overall effects of sampling time on mean methylation of OXTR ₁, OXTR ₂ a and BDNF a without and with adjustment for blood cell count as covariates; post-hoc contrasts between sampling times pre-stress, post-stress and follow-up. Results based on multilevel analysis.

	Main effects			Contrasts			Number of observations
	df b	F	p	C1	C2	C3	N
				p	p	p
OXTR1
Overall model	2; 802	25.84	<0.001	0.009	<0.001	<0.001	600
Adjusted for blood cell count	2; 1133	10.70	<0.001	0.278	<0.001	<0.001	600
OXTR2a
Overall model	2; 2998	2.46	0.086	0.672	0.034	0.099	2045
Adjusted for blood cell count	2; 1368	1.92	0.146	0.536	0.058	0.137	2044
BDNF a
Overall model	2; 1098	1.31	0.271	0.780	0.184	0.139	747
Adjusted for blood cell count	2; 1523	0.87	0.418	0.536	0.518	0.191	737

Abbreviations: BDNF, brain-derived neurotrophic factor; C1, contrast pre-stress versus post-stress; C2, contrast post-stress versus 90 min after stress; C3, contrast pre-stress versus 90 min after stress; OXTR, oxytocin receptor.

^aNatural logarithm transformed;

^bNumerator; denominator.