Table 3. Results from sensitivity analyses in NAA levels in the frontal cortex.
| Specified criteria | No. of OCD | No. of HC | No. of studies | No. of datasets | 95% CI lower | 95% CI upper | Z-value | P-value |
|---|---|---|---|---|---|---|---|---|
| No medication | 106 | 77 | 5 | 6 | −1.268 | 0.026 | −1.881 | 0.060 |
| No psychiatric comorbidity | 130 | 125 | 6 | 10 | −0.613 | 0.273 | −0.753 | 0.452 |
| Cre ratio | 156 | 151 | 7 | 12 | −0.536 | 0.135 | −1.173 | 0.241 |
| 1.5-Tesla scanner | 193 | 175 | 9 | 14 | −0.713 | −0.092 | −2.538 | 0.011 |
| Segmented within VOIs | 66 | 78 | 3 | 4 | −1.035 | −0.357 | −4.023 | <0.001 |
Abbreviations: CI, confidence interval; VOI, volume of interest; mPFC, medial prefrontal cortex; NAA, N-acetylaspartate; OCD, obsessive-compulsive disorder; HC, healthy control.