Table 1. WTCCC pathway enrichment.
| Pathway | P-value | Genes in network |
|---|---|---|
| Wnt signaling pathway(P)a | 0.0008 | CTNNA2, DACT1, FBXW11, CDH16, CDH18, CDH10, CDH11, GNA14, SMARCA2, CDH2, CHD1L, FHL2, PRICKLE1, FAT3, HOXA6 |
| Neuroactive ligand-receptor interaction(K) | 0.0008 | GRIN2B, GRIK2, GABRB1, NTSR1, CYSLTR2, ADRA2A, GABRG3, ADRB2, HRH2, LEP |
| Cadherin signaling pathway(P)a | 0.004 | CTNNA2, CDH16, CDH18, CDH10, CDH11, CDH2, FAT3 |
| Shigellosis(K) | 0.0054 | ELMO1, FBXW11, DOCK1, ABL1 |
| Bacterial invasion of epithelial cells(K) | 0.0085 | CTNNA2, ELMO1, CAV3, DOCK1 |
| Calcium signaling pathway(K) | 0.0141 | ATP2B1, GNA14, NTSR1, CYSLTR2, ADRB2, HRH2 |
| CFTR and beta 2 adrenergic receptor (b2ar) pathway(B) | 0.019 | AGT, ADRB2 |
| Circadian rhythm—mammal(K) | 0.027 | FBXW11, BHLHE40 |
| Signaling events mediated by HDAC class III(N) | 0.0292 | PPARGC1A, FHL2 |
| Receptor-ligand complexes bind G proteins(R) | 0.0302 | AGT, GNA14, ADRA2A, ADRB2, HRH2 |
| ID(C) | 0.0315 | ADD1, ID2 |
| Corticosteroids and cardioprotection(B) | 0.0315 | AGT, ADRB2 |
| β-Arrestins in gpcr desensitization(B) | 0.0338 | AGT, ADRB2 |
| Activation of camp-dependent protein kinase pka(B) | 0.0338 | AGT, ADRB2 |
| Role of β-arrestins in the activation and targeting of map kinases(B) | 0.0387 | AGT, ADRB2 |
| O-glycan biosynthesis(K) | 0.0438 | GCNT1, GALNTL4 |
| Roles of β arrestin-dependent recruitment of src kinases in gpcr signaling(B) | 0.0491 | AGT, ADRB2 |
Genes were prioritized by epistasis network analysis as described in the Materials and methods. Pathways are shown with adjusted hypergeometric enrichment P-value<0.05.
a
These pathways suggest replication in the NIMH-BD GWAS for European ancestry (see Table 2).