Table 3. Top genes from epistasis network centrality of combined WTCCC+NIMH GWAS.
| Chromosome | SNP rs-id | Gene symbol | SNPrank score | Univaraite odds ratio | Univariate P-value |
|---|---|---|---|---|---|
| 5 | rs393291 | DAP | 7.61E-03 | 1.05 | 0.6388 |
| 10 | rs10509126 | ANK3 | 6.64E-03 | 1.192 | 0.01619 |
| 2 | rs10190186 | FHL2 | 6.63E-03 | 1.195 | 0.01106 |
| 4 | rs7679912 | ARAP2 | 6.41E-03 | 1.209 | 0.009473 |
| 3 | rs6773049 | ZIC1 | 6.30E-03 | 1.143 | 0.07756 |
| 12 | rs983421 | SUDS3 | 6.29E-03 | 1.154 | 0.05072 |
| 13 | rs606568 | DGKH | 6.28E-03 | 0.8816 | 0.1125 |
| 13 | rs17088579 | OR7E156P | 6.27E-03 | 1.123 | 0.1374 |
| 12 | rs4135067 | TDG | 6.17E-03 | 1.091 | 0.2667 |
| 10 | rs2094179 | KLF6 | 6.05E-03 | 1.122 | 0.1266 |
| 1 | rs640718 | KMO | 6.00E-03 | 1.192 | 0.009732 |
| 1 | rs17484306 | RRAGC | 5.97E-03 | 1.231 | 0.00339 |
| 6 | rs3736712 | WDR27 | 5.93E-03 | 1.137 | 0.06991 |
| 11 | rs12275977 | GALNTL4 | 5.92E-03 | 1.127 | 0.09964 |
| 11 | rs6591941 | ODZ4 | 5.84E-03 | 1.04 | 0.6031 |
| 3 | rs614566 | LAMP3 | 5.80E-03 | 1.204 | 0.005761 |
| 14 | rs6574988 | GPR65 | 5.80E-03 | 1.234 | 0.0003089 |
| 1 | rs495489 | POGK | 5.79E-03 | 0.9191 | 0.2722 |
| 1 | rs11161999 | LMO4 | 5.70E-03 | 1.193 | 0.007684 |
| 18 | rs17082921 | SOCS6 | 5.69E-03 | 1.144 | 0.07807 |
| 9 | rs17063814 | GNA14 | 5.62E-03 | 1.21 | 0.002639 |
| 14 | rs12588812 | RNASE1 | 5.55E-03 | 1.137 | 0.07456 |
| 3 | rs16852539 | GOLIM4 | 5.53E-03 | 1.073 | 0.2998 |
| 4 | rs7680321 | GABRB1 | 5.51E-03 | 1.25 | 0.0001764 |
| 8 | rs448578 | MSR1 | 5.50E-03 | 1.111 | 0.1176 |
| 8 | rs17069985 | CSMD1 | 5.49E-03 | 1.105 | 0.1615 |
| 1 | rs1890038 | CHD1L | 5.48E-03 | 1.137 | 0.05786 |
| 10 | rs10443995 | DOCK1 | 5.48E-03 | 1.047 | 0.5138 |
| 9 | rs13290547 | DAB2IP | 5.47E-03 | 1.192 | 0.01176 |
| 3 | rs9824570 | CLSTN2 | 5.45E-03 | 0.92 | 0.1817 |
| 16 | rs4843366 | LOC732275 | 5.44E-03 | 1.162 | 0.013 |
| 10 | rs1338007 | ADRA2A | 5.44E-03 | 1.075 | 0.3076 |
| 9 | rs615928 | GCNT1 | 5.44E-03 | 1.099 | 0.2024 |
| 14 | rs10137389 | C14orf106 | 5.43E-03 | 1.084 | 0.2648 |
| 7 | rs56183050 | POT1 | 5.43E-03 | 1.095 | 0.1748 |
| 12 | rs2468244 | CEP290 | 5.42E-03 | 1.096 | 0.1677 |
| 9 | rs3780621 | COL15A1 | 5.41E-03 | 1.157 | 0.01337 |
| 1 | rs6684324 | INADL | 5.41E-03 | 1.204 | 0.003692 |
| 13 | rs9514132 | SLC10A2 | 5.38E-03 | 0.9617 | 0.6074 |
| 1 | rs1318222 | C1orf94 | 5.37E-03 | 1.123 | 0.08309 |
| 18 | rs1560398 | MC4R | 5.36E-03 | 1.035 | 0.6496 |
| 5 | rs17653341 | ADRB2 | 5.32E-03 | 1.055 | 0.4495 |
| 1 | rs12046987 | MIR101-1 | 5.30E-03 | 1.158 | 0.02022 |
| 6 | rs7739908 | OGFRL1 | 5.29E-03 | 1.165 | 0.02408 |
| 18 | rs17739703 | C18orf34 | 5.28E-03 | 0.9017 | 0.1245 |
| 12 | rs1861674 | LOH12CR1 | 5.28E-03 | 1.204 | 0.001111 |
| 7 | rs7785575 | ELMO1 | 5.28E-03 | 1.117 | 0.08243 |
Top genes found by the epistasis network analysis workflow described in the Materials and methods for the merged WTCCC+NIMH-EA data sets. Rows are sorted by SNPrank epistasis network centrality score. Columns are chromosome, SNP rsid, gene symbol, SNPrank score and univariate odds ratio and P-value.Bold gene symbols are genes that have strong evidence from univariate analysis of other larger-scale GWAS of BD. Ranking for unmerged data may be found in Supplementary Table 1.