Table 3.
Pregnancy and pregnancy outcome in FD females and controls
| Fabry (n = 62) | Control (n = 53) | OR (95% CI) | p valuea | |
|---|---|---|---|---|
| Pregnancy outcome | ||||
| Hypertension during pregnancy # | 11/32 (34%) | 5/35 (14%) | 3.14 (0.95-10.4) | 0.05 |
| Proteinuria during pregnancy | 11/32 (34%) | 0/35 (0%) | NA | <0.001 |
| Preeclampsia # | 3/32 (9.4%) | 0/35 (0%) | NA | 0.10 |
| Premature delivery # | 6/32 (19%) | 2/35 (5.7%) | 3.81 (0.71-20.4) | 0.14 |
| Induced labour | 7/32 (22%) | 5/35 (14%) | 1.68 (0.47-5.95) | 0.42 |
| Pelvic instability # | 2/32 (6.2%) | 4/35 (11%) | 0.52 (0.09-3.03) | 0.68 |
| Microsomia # | 3/32 (9.4%) | 1/35 (2.9%) | 3.52 (0.35-35.7) | 0.34 |
| Macrosomia # | 1/32 (3.1%) | 1/35 (2.9%) | 1.10 (0.07-18.3) | 1.00 |
| Postpartum bleeding # | 3/32 (9.4%) | 5/35 (15%) | 0.62 (0.14-2.84) | 0.71 |
| Retained placenta # | 4/32 (13%) | 6/35 (17%) | 0.69 (0.18-2.71) | 0.74 |
| Miscarriage | 8/32 (25%) | 4/35 (11%) | 2.58 (0.69-9.61) | 0.15 |
| Intrauterine death | 1/32 (3.1%) | 1/35 (2.9%) | 1.10 (0.07-18.3) | 1.00 |
Data are numbers (%). OR = odds ratio. Bold: significant after Bonferroni correction. NA = not applicable. aAccording to Pearson chi-square test. # Fisher’s exact test because of small sample size.