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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Crit Rev Biochem Mol Biol. 2012 Jun 7;47(5):444–463. doi: 10.3109/10409238.2012.694846

Figure 2.

Figure 2

Model of PTC suppression. A) The eRF1/eRF3 complex efficiently mediates translation termination in eukaryotes, where incorporation of an amino acid carried by a near-cognate aminoacyl-tRNA into the nascent polypeptide is rare. B) Drugs such as aminoglycosides bind to the small ribosomal subunit to stimulate misreading at stop codons, leading to an increased frequency of near-cognate aminoacyl-tRNA incorporation that allows continued translation elongation in the correct ribosomal reading frame. [Note: a color version of this figure is available online.]