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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Crit Rev Biochem Mol Biol. 2012 Jun 7;47(5):444–463. doi: 10.3109/10409238.2012.694846

Figure 4.

Figure 4

Key differences between the prokaryotic and eukaryotic decoding sites. E. coli numbering is shown for prokaryotes (orange), while S. cerevisiae numbering is shown for eukaryotes (green). Arrows indicate nucleotides that are key in decoding correct base pair interactions within the A site. The boxed nucleotides indicate differing residues between prokaryotic and eukaryotic decoding sites that affect the affinity of aminoglycoside binding. [Note: a color version of this figure is available online.]