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. Author manuscript; available in PMC: 2012 Sep 2.
Published in final edited form as: Exp Gerontol. 2010 Sep 16;46(2-3):155–163. doi: 10.1016/j.exger.2010.08.030

Figure 1.

Figure 1

Activation of mTORC1 in neurons. A) mTORC1 activation by LTP-inducing stimulus. Tetanic stimualation results in depolarization and opening of NMDA receptor channels. The resulting influx of calcium triggers activation of PI3K, ERK/MAPK, and cAMP/PKA pathways. Resulting activation of ERK1/2 and Akt inhibit TSC1/2, removing constraint on Rheb kinase. Akt activation also serves to remove inhibition of the mTORC1 complex by PRAS40. Removal of these constraints allow for mTORC1-depend phosphorylation of S6K and 4E-BP2, which promotes translation, including for mRNAs with known functions in synaptic function. B) mTORC1 activation in the hypothamalus can suppress feeding behavior. Leptin activates JAK/STAT and PI3K signaling pathways. As above, PI3K activity can remove inhibition of mTORC1 activity. In addition, aminio acids can increase mTORC1 activity in part through the inhibition of TSC2. Activation of mTORC1 suppresses feeding behavior in an S6 kinase dependent manner.