Table 2.
Summary of cytokines and chemokines produced during RSV infection
Cytokine | Source | Effects |
---|---|---|
IFN-γ | NK cells, CD4+ T cells, CD8+ T cells | Increases NK activation, Th1 differentiation |
IL-1β | Macrophages | Increases expression of cytokines mediated by NF-κB |
IL-4 | CD4+ T cells | Increases Th2 differentiation, decreases Th1 differentiation |
IL-8 | Epithelial cells, Macrophages | Neutrophil recruitment |
IL-10 | CD4+ T cells | Inhibits expression of inflammatory cytokines, suppresses inflammatory response |
IL-17A | CD4+ T cells | Increases Th17 differentiation, increases inflammatory cytokine production |