Table 2. PLGA repeating sequence copolymer characterization data.
| Polymer | Repeating Patterna | Yield (%)b | THF | CHCl3 | CHCl3 | CHCl3 | ||
|---|---|---|---|---|---|---|---|---|
| Mn (kDa)c | PDIc | Mn (kDa)c | PDIc | Absolute Mnd | DPe,f | |||
| LG |
|
63 | 27.4 | 1.3 | 33.3 | 1.3 | 13.4 | 512 (206) |
| LracG |
|
52 | 28.8 | 1.3 | 34.3 | 1.4 | --- | 527 |
| GLG |
|
78 | 26.2 | 1.2 | 36.2 | 1.4 | 19.4 | 577 (309) |
| GLracG |
|
60 | 21.4 | 1.3 | 27.5 | 1.4 | --- | 439 |
| LLG |
|
70 | 41.2 | 1.2 | 41.8 | 1.3 | 23.1 | 620 (343) |
| LLRG |
|
71 | 29.0 | 1.4 | 42.3 | 1.3 | --- | 628 |
| LRLG |
|
59 | 30.6 | 1.4 | 39.8 | 1.4 | --- | 591 |
| LracLracG |
|
65 | 30.5 | 1.4 | 35.2 | 1.3 | --- | 522 |
| LLracG |
|
50 | 17.8 | 1.4 | 19.3 | 1.6 | --- | 286 |
| LracLG |
|
83 | 27.4 | 1.4 | 40.5 | 1.4 | 25.9 | 601 (384) |
| Ld,racLG |
|
99 | 32.8 | 1.3 | 31.7 | 1.5 | --- | 468 |
| LLd,racG |
|
62 | 29.6 | 1.4 | 33.7 | 1.4 | --- | 498 |
| GLGd2 |
|
52 | 15.2 | 1.4 | 25.3 | 1.5 | --- | 400 |
| GLGLR |
|
65 | 12.3 | 1.5 | 21.1 | 1.4 | --- | 324 |
| LLGLLRG |
|
70 | 30.0 | 1.4 | 32.0 | 1.5 | --- | 475 |
| LRLGLLG |
|
63 | 30.1 | 1.4 | 39.8 | 1.3 | --- | 591 |
a
(S)-lactic unit,
(R)-lactic unit,
rac-lactic unit,
glycolic unit
deuterated unit;
b
Isolated after 2× precipitation in MeOH;
c
Determined by SEC relative to PS standards;
d
Determined by SEC-MALLS;
e
DP from SEC data based on number of lactic and glycolic monomers;
f
(DP) from SEC-MALLS data based on number of lactic and glycolic monomers.