Table 4.
Multivariate logistic regression analysis testing for independent effects of suspected risk factors, as well as for a potential gene-environment interaction. The used best-fit model is based on the following variables in the crude model: income, family history, passive smoking at the work place, occupational exposure to combustion fumes, previous history of prostate-related symptoms, and history of urinary tract infections.
| Variable | Testing for independent effect | Testing for potential gene-environment interaction | ||
|---|---|---|---|---|
| NAT1 *14A | NAT1 *10 | |||
| Adjusted OR (CI) |
Adjusted OR (CI) | Adjusted OR(CI) | Noneadjusted OR (CI) |
|
| Income (reference < 500 $/month) | ||||
| 500–1000 | 2.14 (0.4–11.4) |
1.06 (0.05–21.2) |
5.87 (0.26–133.2) | 14.59 (0.04–5318.5) |
| >1000 | 7.45 (0.91–61.2) |
2.18 (0.04–114.1) | 10.81 (0.085–1369.54) | 11.45 (0.098–1334.9) |
|
| ||||
| Smoking | 1.02* (1.01–1.04) |
1.024* (0.991–1.06) | 1.017 (0.99–1.04) | 1.039 (0.98–1.104) |
|
| ||||
| Occupational exposure to combustion fumes (reference none) | 4.34 (0.83–22.6) |
2.17 (0.07–70.33) | 7.12 (0.28–182.8) | 12.94 (0.00−) |
|
| ||||
| Prostate-related symptoms (reference: none) | 7.81* (1.14–53.41) |
2.94 (0.00−) |
3.04 (0.074–125.1) | |
|
| ||||
| Allele (reference: none) | ||||
| NAT1 *14A | 6.937* (1.19–4.04) |
|||
| NAT1 *10 | 0.741 (0.099–5.54) |
|||
| NagelKerke R 2 | 0.597 | 0.64 | 0.442 | 0.46 |
*Significant at or less than 0.05.