Table 1.

Summary of plate-based ELISA measurements for TB biomarkers LAM, ESAT6, and Ag85 complex. The NS binding and the signal measured at the LoD are shown for all three biomarkers, when diluted in serum/urine. The LoD measured on the waveguide-based platform is also indicated.

Sample	Biomarker	Optical Density		Limit of Detection (pM)
		Control	Positive	ELISA	Waveguide
Serum	Ag85	0.06 ± 0.01	0.24 ±0.01	183000	0.5a
Serum	ESAT6	0.31 ± 0.1	0.9 ± 0.4	125000	100
Urine	LAM	0.13 ± 0.005	0.18 ± 0.006	78000	1

^aLoD for Ag85 derived from two measurements. A complete standard curve was not generated because of poor antibody stability