Table 1.
Tumor Cell Expression of CD137 Protein Determined by Immunohistochemistry
| Tumor subtype | Total positive (n/N) | % Positive |
|---|---|---|
| Histiocytic and dendritic cell neoplasms (n = 23) | 6/23 | 26 |
| Follicular dendritic cell sarcoma | 6/7 | 86 |
| Interdigitating dendritic cell tumor | 0/1 | 0 |
| Langerhans cell histiocytosis | 0/10 | 0 |
| Rosai-Dorfman disease | 0/3 | 0 |
| Histiocytic sarcoma | 0/2 | 0 |
| Hodgkin lymphoma (n = 225) | 179/225 | 80 |
| Classical Hodgkin lymphoma (CHL) | 179/208 | 86 |
| Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) | 0/17 | 0 |
| T-cell lymphoma (n = 80) | 46/80 | 58 |
| T-lymphoblastic lymphoma/leukemia | 0/7 | 0 |
| Peripheral T-cell lymphoma, not otherwise specified (PTCL NOS) | 9/16 | 56 |
| Angioimmunoblastic T-cell lymphoma (AITL) | 18/32 | 56 |
| Mycosis fungoides | 6/7 | 86 |
| Large T-cell lymphoma, transformed from mycosis fungoides | 7/9 | 78 |
| Subcutaneous panniculitis-like T-cell lymphoma | 1/1 | 100 |
| Anaplastic large cell lymphoma (ALK+ and ALK−) | 5/8 | 63 |
| Extranodal NK/T-cell lymphoma, nasal type | 34/93 | 37 |
| B-cell lymphoma (n = 359) | 12/359 | 3 |
| Follicular lymphoma | 0/134 | 0 |
| Grade 1 and 2 | 0/84 | 0 |
| Grade 3A and 3B | 0/50 | 0 |
| Diffuse large B-cell lymphoma (DLBCL) | 0/95 | 0 |
| Primary mediastinal large B-cell lymphoma (PMBL) | 7/46 | 15 |
| B-cell lymphoma, unclassifiable (features intermediate between DLBCL and CHL)⁎ | 5/10 | 50 |
| Burkitt's lymphoma | 0/3 | 0 |
| Extranodal marginal zone lymphoma | 0/10 | 0 |
| Splenic marginal zone lymphoma | 0/5 | 0 |
| Nodal marginal zone lymphoma | 0/3 | 0 |
| Mantle cell lymphoma | 0/12 | 0 |
| Chronic lymphocytic leukemia/small cell lymphocytic leukemia (CLL/SLL) | 0/30 | 0 |
| Lymphoplasmacytic lymphoma | 0/4 | 0 |
| B-lymphoblastic lymphoma/leukemia | 0/5 | 0 |
| Post-transplant lymphoproliferative disorder | 0/2 | 0 |
| Plasma cell neoplasms (n = 158) | 0/158 | 0 |
| Monoclonal gammopathy of undetermined significance (MGUS) | 0/8 | 0 |
| Multiple myeloma | 0/131 | 0 |
| Plasma cell leukemia | 0/11 | 0 |
| Plasmacytoma | 0/8 | 0 |
| Other (n = 17) | ||
| Systemic mast cell disease | 0/2 | 0 |
| Acute myeloid leukemia (various WHO subtypes) | 0/11 | 0 |
| Blastic plasmacytoid dendritic cell neoplasm | 1/4 | 25 |
⁎
Referred to in the text as BCLU/DLBCL/CHL.