Table 4.
Effect of Lovastatin (LOV) and Calcitriol Combination on Cytokines in the Spinal Cords of Experimental Autoimmune Encephalomyelitis (EAE) Rats
| Groups | CON | CON + LOV + calcitriol | EAE | EAE + LOV | EAE + calcitriol | EAE + LOV + calcitriol |
|---|---|---|---|---|---|---|
| IL-1β | 150 ± 41 | 122 ± 35 | 625 ± 26 | 389 ± 38⁎⁎ | 344 ± 75⁎⁎ | 169 ± 39⁎⁎⁎ |
| TNF-α | 6 ± 2.2 | 9.6 ± 2 | 38 ± 4 | 19.3 ± 1.8⁎⁎ | 15.1 ± 3.9⁎⁎ | 10.8 ± 0.2⁎⁎⁎ |
| IL-17A | 30 ± 4.5 | 29 ± 7.5 | 226 ± 15 | 93 ± 0.2⁎⁎ | 116 ± 22.3⁎⁎ | 28 ± 9⁎⁎⁎ |
| IL-6 | 15 ± 0.9 | 22 ± 6 | 129 ± 8 | 46.2 ± 3⁎⁎ | 61 ± 5⁎⁎ | 29 ± 3⁎⁎⁎ |
| TGF-β1 | 10 ± 2 | 13 ± 2.3 | 25 ± 3.6 | 71 ± 11⁎⁎ | 79 ± 7⁎⁎ | 161 ± 12⁎⁎⁎ |
| IL-10 | 7 ± 0.2 | 9 ± 2.1 | 15 ± 2.8 | 45 ± 8⁎⁎ | 53 ± 5.7⁎⁎ | 123 ± 21.4⁎⁎⁎ |
Concentration of cytokines and neurotrophic factors (pg/mg of spinal cord tissue homogenate) shown as composite mean ± SEM (n = 10 to 12) evaluated in three separate experiments. Statistical tests were performed using one-way multiple-range analysis of variance followed by Benferrroni post-test correction. Statistical significance:
⁎⁎
P < 0.01 and
⁎⁎⁎
P < 0.001 versus EAE plus vehicle.