Figure 6.

Pulmonary physiology exacerbated in ethanol-gavaged mice. A: Enhanced pause (PenH). A significant increase in PenH was observed in sensitized mice gavaged with ethanol. No changes in PenH were noted for any other group. B: Breathing frequency (F). Breathing frequency was significantly depressed in ethanol-gavaged sensitized mice at all doses challenged. C: Time of inspiration (Ti). Inspiratory time was significantly increased in sensitized mice gavaged with ethanol. Normal mice gavaged with ethanol and sensitized mice gavaged with water also show slight Ti increases in response to methacholine. D: Time of expiration (Te). Expiratory time was significantly lengthened in ethanol-gavaged sensitized mice. Data are mean ± SEM, n = 3 to 7 per group. *P < 0.05, ***P < 0.001 versus sensitized mice at that dose; ^†P < 0.05 normal mice versus normal + ethanol, two-way analysis of variance with Bonferroni posttests.