Table 1.
Comparison of Asthmatic Parameters in Normal (Naive) and CRA-Sensitized Mice
| Parameter | Normal | Sensitized | P value |
|---|---|---|---|
| CRA-specific IgE (OD) | 0.223 ± 0.011 | 0.288 ± 0.015 | 0.007 |
| Eosinophils (per mL blood) | 5 ± 2 | 24 ± 10 | 0.126 |
| BAL eosinophils (per mouse) | 386 ± 96 | 7746 ± 2292 | 0.023 |
| Mast cells (per 10 lung slices) | 2.5 ± 2.5 | 22.5 ± 6.2 | 0.053 |
| Mucus (mean gray area × 1000) | 28 ± 9 | 125 ± 30 | 0.020 |
| PenH (25 mg/mL methacholine) | 0.436 ± 0.017 | 0.620 ± 0.051 | 0.028 |
Sensitized mice were immunized with cockroach allergens on Days 0 and 14 and then studied on Day 21, ie, 7 days after the last exposure to allergen. The final allergen exposure typically given on Day 21 was not administered.
OD, optical density.