Table 1.
mRNA Expression of Fgα, Fgβ, and Fgγ Significantly Increases after Ischemia/Reperfusion or Cisplatin-Induced Kidney Tubular Injury
| Treatment | mRNA expression (fold change relative to sham/0 hours) |
|||
|---|---|---|---|---|
| Fgα | Fgβ | Fgγ | Kim-1 | |
| Ischemia/reperfusion, cortex | ||||
| sham | 1.0 ± 0.1 | 1.0 ± 0.1 | 1.0 ± 0.2 | 1.0 ± 0.3 |
| 24 hours | 3.0 ± 0.6⁎ | 22.3 ± 7.6⁎ | 17.1 ± 4.0⁎ | 364.7 ± 32.8⁎ |
| 72 hours | 2.9 ± 0.4⁎ | 26.2 ± 5.9⁎ | 8.2 ± 1.1⁎ | 208.9 ± 55.1⁎ |
| 120 hours | 4.4 ± 1.0⁎ | 23.1 ± 7.8⁎ | 13.6 ± 2.2⁎ | 125.8 ± 35.4⁎ |
| 168 hours | 4.6 ± 0.1⁎ | 19.3 ± 4.0 | 8.2 ± 1.3 | 108.5 ± 41.2⁎ |
| Ischemia/reperfusion, medulla | ||||
| sham | 1.0 ± 0.2 | 1.0 ± 0.2 | 1.0 ± 0.2 | 1.0 ± 0.1 |
| 24 hours | 3.8 ± 0.6⁎ | 40.2 ± 8.7⁎ | 4.8 ± 1.6⁎ | 325.9 ± 95.7⁎ |
| 72 hours | 6.1 ± 1.8⁎ | 75.6 ± 24.8⁎ | 9.6 ± 2.4 | 318.2 ± 144.3 |
| 120 hours | 5.0 ± 2.1 | 46.8 ± 23.4 | 9.6 ± 3.9 | 159.1 ± 67.6 |
| 168 hours | 2.9 ± 1.0 | 27.6 ± 11.1⁎ | 2.8 ± 0.9 | 76.7 ± 40.7 |
| Cisplatin, 20 mg/kg | ||||
| 0 hours | 1.0 ± 0.0 | 1.0 ± 0.5 | 1.0 ± 0.2 | 1.0 ± 0.1 |
| 24 hours | 9.6 ± 2.5⁎ | 1.8 ± 0.3 | 25.0 ± 7.8⁎ | 5.0 ± 1.0⁎ |
| 48 hours | 27.8 ± 7.0⁎ | 17.3 ± 6.8⁎ | 183.2 ± 46.6⁎ | 18.1 ± 4.8⁎ |
| 72 hours | 25.3 ± 2.9⁎ | 23.0 ± 7.6⁎ | 242.4 ± 32.3⁎ | 23.9 ± 2.7⁎ |
Data are expressed as mean fold change ± SEM relative to sham-treated rats (I/R) or vehicle-treated mice.
⁎
P < 0.05 Student's t-test.