Table 2.
mRNA Expression of Fgα, Fgβ, and Fgγ and Urinary Excretion of Fibrinogen Does Not Increase after Galactosamine-Induced Liver Toxicity
| Measure | Galactosamine treatment |
|
|---|---|---|
| 0 g/kg | 1.1 g/kg | |
| Histopathological score | ||
| Kidney | 0 | 0 |
| Liver | 0 | 2 |
| Clinical chemistry | ||
| BUN (mg/dL) | 19.9 ± 0.8 | 19.1 ± 1.1 |
| SCr (mg/dL) | 0.5 ± 0.0 | 0.5 ± 0.0 |
| ALT (U/L) | 26.0 ± 1.9 | 422.8 ± 121.9⁎ |
| AST (U/L) | 42.5 ± 3.9 | 246.0 ± 57.5 |
| Gene expression, kidney (fold change relative to control) | ||
| Fgα | 1.0 ± 0.2 | 1.2 ± 0.1 |
| Fgβ | 1.0 ± 0.1 | 1.0 ± 0.0 |
| Fgγ | 1.0 ± 0.1 | 0.9 ± 0.1 |
| Kim-1 | 1.0 ± 0.1 | 1.0 ± 0.1 |
| Urinary excretion | ||
| Fg (ng/mg uCr) | 201.9 ± 38.1 | 26.0 ± 26.0 |
Data are expressed as means ± SEM.
ALT, alanine transaminase; AST, aspartate transaminase; BUN, blood urea nitrogen; SCr, serum creatinine; uCr, urine creatinine.
⁎
P < 0.05 Student's t-test.