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. 2012 Sep;181(3):897–906. doi: 10.1016/j.ajpath.2012.05.032

Figure 3.

Figure 3

Mϕ-TGF-βRIIKO mice generate enhanced type 2 immunity against the hookworm N. brasiliensis. A: WT mice (open symbols) and Mϕ-TGF-βRIIKO mice (closed symbols) were subcutaneously infected with 750 N. brasiliensis infective-stage larvae (L3) and were evaluated for fecal egg production from adult worms in the intestinal lumen. B: Untreated (naïve) or infected mice from both strains were evaluated for total serum levels of IgE. C: Systemic levels of IL-4, IFN-γ and IL-10 were determined by in vivo cytokine capture assay. D and E: Levels in BALF of TGF-β (D) and IL-13 (E), as determined by sandwich ELISA. Data are expressed as means ± SEM and are representative of four independent experiments. *P < 0.05; **P < 0.01. n = 6 to 8 mice per group. N.D., not detected.