Figure 4.

Molecularly suppressing expression of p53 restores the ability of PDGFRα-deficient cells to induce retinal detachment. The cells described in the legend to Figure 3A are compared for their PVR potential in a rabbit model of this disease. Inset: The type of lenti-shRNA used to modify the cells. PVR is induced as described in Materials and Methods. Each symbol represents the response of an individual rabbit on the indicated day. The data are subjected to an unpaired t-test or a one-way analysis of variance. The asterisk denotes a statistically significant difference.