Figure 7.

p53 Attenuates HV-driven collagen gel contraction. A: The impact of Nutlin-3 on HV-mediated signaling events. The experiment is the same as in Figure 3A, except RPE cells from a patient epiretinal membrane are used in place of RCF, and HV (a pool of vitreous from five patients with PVR, diluted 1:3 in DMEM) is used in place of RV. The data presented are representative of three independent experiments. B: The impact of Nutlin-3 on HV-mediated contraction. The experiment is the same as in Figure 3B, with the modification noted in Figure 5A. The data are subjected to a paired t-test. The asterisk denotes a statistically significant difference. The data shown are representative of three independent experiments.