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Anti-LPA mAb (B3) reduces microglia activation around the lesion site. One week after SCI, CD11b immunostaining in isotype-treated control mice (A, and C) compared with reduced levels in B3-treated mice (B and D). E: Quantitative analysis of the reactive microglia marker CD11b from 200-mm2 areas adjacent to the lesion site. Results are the mean ± SEM (n = 7 in each group). *P < 0.001 by two-tailed t-test, 95% confidence). Scale bar s: 100 μm (A and B); 50 μm (C and D).
