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. 2012 Sep;181(3):978–992. doi: 10.1016/j.ajpath.2012.06.007

Figure 7.

Figure 7

Anti-LPA mAb (B3) increases neuronal survival and synaptic densities at the lesion site. A–C: Eight weeks after SCI, in B3-treated mice, significantly more traced neurons (arrowheads) are observed in the areas adjacent and proximal to the lesion site (n = 7) compared with controls (n = 8). D–F: Quantitation of synaptic density around the traced neuronal cells shows significantly more synapses in B3-treated mice compared with isotype-treated control mice. TMRD, tetramethylrhodamine dextran. Results are mean ± SEM cell number or density in the field. *P < 0.001 by two-tailed t-test, 95% confidence. Scale bars: 100 μm (B and C); 25 μm (E and F).