Table 2.
Odds Ratios (OR) and 95% Confidence Intervals (CI) for transporter gene related SNPs with B-NHL, HL and CLL in samples of the Epilymph study. Only SNPs with at least an association showing p<0.01 are presented. Significant associations after correction for multiple testing (p≤0.001) are highlighted in bold).
| Genotype | Controls* | B-NHL | CLL | Controls* | HL | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| N (%) | N (%) | OR† (95% CI) | p | N (%) | OR (95%CI) | p | N (%) | N (%) | OR (95%CI) | p | |
| ABCC2 rs3740067 | |||||||||||
| CC | 450 (38) | 418 (39) | Reference | 129 (40) | Reference | 417 (36) | 115 (44) | Reference | |||
| CG | 562 (47) | 493 (46) | 0.95 (0.79–1.13) | 0.5 | 145 (45) | 0.90 (0.68–1.18) | 0.4 | 569 (49) | 105 (41) | 0.63 (0.46–0.87) | 0.004 |
| GG | 183 (15) | 151 (14) | 0.90 (0.69–1.16) | 0.4 | 46 (14) | 0.89 (0.60–1.31) | 0.6 | 170 (5) | 39 (15) | 0.7 (0.45–1.09) | 0.1 |
| CG/GG | 0.93 (0.79–1.11) | 0.4 | 0.90 (0.69–1.16) | 0.4 | 0.65 (0.48–0.87) | 0.004 | |||||
| p-trend | 0.4 | p-trend | 0.5 | p-trend | 0.02 | ||||||
| ABCG2 rs1481012 | |||||||||||
| AA | 959 (80) | 902 (85) | Reference | 284 (88) | Reference | 923 (80) | 224 (86) | Reference | |||
| AG | 228 (19) | 155 (15) | 0.71 (0.57–0.90) | 0.004 | 33 (10) | 0.50 (0.33–0.74) | 0.0005 | 220 (19) | 33 (13) | 0.61 (0.40–0.93) | 0.02 |
| GG | 9 (1) | 10 (1) | 1.15 (0.47–2.86) | 0.8 | 4 (1) | 1.57 (0.47–5.26) | 0.5 | 13 (1) | 2 (1) | 0.51 (0.10–2.53) | 0.4 |
| AG/GG | 0.73 (0.59–0.91) | 0.005 | 0.54 (0.37–0.78) | 0.001 | 0.60 (0.40–0.91) | 0.02 | |||||
| p-trend | 0.01 | p-trend | 0.005 | p-trend | 0.02 | ||||||
| ABCG2 rs1564481 | |||||||||||
| GG | 501 (42) | 407 (38) | Reference | 121 (38) | Reference | 473 (41) | 95 (37) | Reference | |||
| GA | 564 (47) | 496 (46) | 1.08 (0.90–1.29) | 0.4 | 145 (45) | 1.08 (0.82–1.42) | 0.6 | 554 (48) | 128 (49) | 1.26 (0.92–1.74) | 0.2 |
| AA | 131 (11) | 164 (15) | 1.54 (1.18–2.00) | 0.002 | 55 (17) | 1.85 (1.26–2.71) | 0.002 | 129 (11) | 36 (14) | 1.43 (0.90–2.28) | 0.1 |
| GA/AA | 1.17 (0.98–1.38) | 0.08 | 1.22 (0.94–1.58) | 0.1 | 1.30 (0.96–1.75) | 0.09 | |||||
| p-trend | 0.002 | p-trend | 0.007 | p-trend | 0.08 | ||||||
| ABCG2 rs2231142 | |||||||||||
| CC | 957 (80) | 898 (84) | Reference | 284 (88) | Reference | 921 (80) | 224 (86) | Reference | |||
| CA | 229 (19) | 158 (15) | 0.73 (0.58–0.91) | 0.005 | 33 (10) | 0.49 (0.33–0.73) | 0.0004 | 221 (19) | 33 (13) | 0.60 (0.40–0.92) | 0.02 |
| AA | 10 (1) | 11 (1) | 1.15 (0.49–2.74) | 0.7 | 4 (1) | 1.42 (0.43–4.65) | 0.6 | 14 (1) | 2 (1) | 0.49 (0.10–2.43) | 0.4 |
| CA/AA | 0.75 (0.60–0.93) | 0.009 | 0.53 (0.36–0.77) | 0.001 | 0.59 (0.39–0.90) | 0.01 | |||||
| p-trend | 0.02 | p-trend | 0.004 | p-trend | 0.01 | ||||||
| ABCG2 rs2725256 | |||||||||||
| AA | 498 (42) | 403 (38) | Reference | 119 (37) | Reference | 469 (41) | 94 (36) | Reference | |||
| AG | 562 (47) | 496 (46) | 1.09 (0.91–1.30) | 0.4 | 146 (45) | 1.10 (0.84–1.45) | 0.5 | 555 (48) | 129 (50) | 1.29 (0.94–1.77) | 0.1 |
| GG | 136 (11) | 168 (16) | 1.52 (1.17–1.98) | 0.002 | 56 (17) | 1.82 (1.25–2.66) | 0.002 | 132 (11) | 36 (14) | 1.40 (0.88–2.23) | 0.2 |
| AG/GG | 1.17 (0.99–1.39) | 0.07 | 1.24 (0.96–1.60) | 0.10 | 1.31 (0.97–1.77) | 0.08 | |||||
| p-trend | 0.005 | p-trend | 0.007 | p-trend | 0.08 | ||||||
| ABCG2 rs6857600 | |||||||||||
| GG | 696 (58) | 693 (65) | Reference | 211 (66) | Reference | 681 (59) | 153 (59) | Reference | |||
| GA | 421 (35) | 319 (30) | 0.76 (0.64–0.91) | 0.003 | 86 (27) | 0.63 (0.47–0.84) | 0.002 | 409 (35) | 84 (32) | 0.94 (0.69–1.30) | 0.7 |
| AA | 79 (7) | 55 (5) | 0.71 (0.49–1.01) | 0.06 | 24 (7) | 0.94 (0.57–1.55) | 0.8 | 66 (6) | 22 (8) | 1.37 (0.77–2.42) | 0.3 |
| GA/AA | 0.75 (0.64–0.90) | 0.001 | 0.68 (0.52–0.88) | 0.004 | 1.01 (0.75–1.36) | 1.0 | |||||
| p-trend | 0.002 | p-trend | 0.03 | p-trend | 0.6 | ||||||
| NR1I2 rs11917714 | |||||||||||
| GG | 822 (69) | 684 (64) | Reference | 215 (67) | Reference | 800 (69) | 164 (63) | Reference | |||
| GA | 333 (28) | 327 (31) | 1.18 (0.98–1.42) | 0.07 | 91 (28) | 1.03 (0.78–1.36) | 0.9 | 319 (28) | 82 (32) | 1.29 (0.94–1.79) | 0.1 |
| AA | 40 (3) | 55 (5) | 1.65 (1.08–2.51) | 0.02 | 15 (5) | 1.44 (0.77–2.70) | 0.3 | 37 (3) | 13 (5) | 1.35 (0.67–2.76) | 0.4 |
| GA/AA | 1.23 (1.03–1.47) | 0.02 | 1.07 (0.82–1.40) | 0.6 | 1.30 (0.96–1.77) | 0.09 | |||||
| p-trend | 0.007 | p-trend | 0.4 | p-trend | 0.1 | ||||||
*
1196 controls were taken into account for the risk analysis with the B-cell lymphoma cases and 1153 controls were taken into account for the risk analysis with the Hodgkin lymphoma cases.
†
Odds Ratios were adjusted for the matching variables: age (continuous), sex and study center (categorical); the common homozygote was used as reference group for each SNP.