Table 3.

Odds Ratios and 95% Confidence Intervals for estimated Haplotypes of the ABCG2 and NR1I2 genes associated with B-NHL and subtypes.

			B-NHL			DLBCL			FL			CLL
Gene	Structure	Freq.	OR*	95% CI	p	OR	95% CI	p	OR	95% CI	p	OR	95% CI	p
ABCG2	Block2†
	A-A-g-C-a	0.36	Reference			Reference			Reference			Reference
	g-A-A-C-G	0.28	0.95	(0.82–1.10)	0.5	0.99	(0.80–1.21)	0.9	0.93	(0.70–1.22)	0.6	0.89	(0.71–1.11)	0.3
	A-A-A-C-G	0.25	0.78	(0.67–0.91)	0.001	0.80	(0.64–0.99)	0.04	0.79	(0.60–1.05)	0.10	0.74	(0.59–0.94)	0.01
	A-g-A-a-G	0.09	0.70	(0.56–0.87)	0.002	0.70	(0.51–0.96)	0.03	0.86	(0.58–1.28)	0.5	0.53	(0.37–0.77)	0.001
NR1I2	Block2‡
	G-A-A-G	0.60	Reference			Reference			Reference			Reference
	a-g-g-G	0.19	1.22	(1.05–1.43)	0.009	1.26	(1.03–1.55)	0.03	1.39	(1.06–1.83)	0.02	1.13	(0.90–1.43)	0.3
	G-g-A-a	0.13	1.09	(0.90–1.30)	0.4	0.90	(0.69–1.18)	0.4	1.28	(0.92–1.77)	0.1	1.20	(0.91–1.57)	0.2
	G-g-g-G	0.08	0.82	(0.66–1.01)	0.07	0.83	(0.62–1.13)	0.2	0.56	(0.34–0.91)	0.02	0.97	(0.70–1.33)	0.8

Abbreviations are explained in Table 2.

^*Odds Ratios were adjusted for the matching variables: age (continuous), sex and study center (categorical); the common haplotype was used as reference group.

^†SNP order: rs13120400-rs1481012-rs2725256-rs2231142-rs1564481. Uppercase letters indicate major allele, lowercase letters denote minor allele

^‡SNP order: rs11917714-rs6785049-rs3732360-rs1054190. Uppercase letters indicate major allele, lowercase letters denote minor allele