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Shown are time-dependent decreases of maximal intensities of cross-peaks arising from backbone amides of (a) Arg24 (kex=(4.12±0.05)·10−4 s−1), (b) Ala45 (kex=(3.27±0.02)·10−5 s−1), (c) Phe49 (kex=(4.14±0.01)·10−6 s−1), (d) Val125 (kex=(5.16±0.04)·10−7 s−1) and (e) Leu110 (kex=(2.15±0.03)·10−8 s−1), respectively. Notice the hugely different time-scales in panels a–e. Data are extracted from 1H-15N HSQC spectra.
