Figure 7.

Sox2 transcriptional activity correlates with tumorogenicity in the SCID xenograft mouse model. Xenografts derived from the Sox2^active subset of SUP-M2 cells were significantly larger than those derived from the Sox2^inactive subset (a, b). A hematoxylin and eosin section of the subcutaneous tumor harvested from an animal xenografted with Sox2^active cells reveals sheets of anaplastic lymphoma cells (c). A high magnification of the splenic tumor from the same animal is illustrated; a megakaryocyte is highlighted by a black arrow (d).