Table 1.
Most abundant miRNAs in the human brain temporal lobe association neocortex; ranked by miRNA numerical designation; based on pooled data from N = 21 short post-mortem interval (PMI) controls; this group included 9 males and 12 females, mean age 72 ± 6.3 years; all PMIs less than 3 h; all of these miRNAs yielded a relative signal strength of 5000 or greater on an LC Sciences miRNA array Genechip (proprietary MRA-1001-miRNA microfluidic chip analytical platform; 1922 small RNAs analyzed; LC Sciences Corporation, Houston, TX, USA) and ranked the top 61 of most abundant miRNAs detected; except for miRNAs listed here, all other miRNAs are in a significantly lower abundance; note high basal abundance of the let-7a to let-7g group of miRNAs; note that AD-abundant miRNAs such as miRNA-155 do not appear in this table as in control brain they are relatively scarce, but are significantly induced as in AD brain, and especially as AD progresses.
| hsa-let-7a-5p | hsa-miR-23b-3p |
| hsa-let-7b-5p | hsa-miR-23c |
| hsa-let-7c | hsa-miR-24-3p |
| hsa-let-7d-5p | hsa-miR-26a-5p |
| hsa-let-7f-5p | hsa-miR-26b-5p |
| hsa-let-7g-5p | hsa-miR-27a-3p |
| hsa-miR-100-5p | hsa-miR-27b-3p |
| hsa-miR-101-3p | hsa-miR-29a-3p |
| hsa-miR-103a-3p | hsa-miR-29b-3p |
| hsa-miR-107 | hsa-miR-29c-3p |
| hsa-miR-124-3p | hsa-miR-30a-5p |
| hsa-miR-125a-5p | hsa-miR-30b-5p |
| hsa-miR-125b-5p | hsa-miR-30c-5p |
| hsa-miR-126-3p | hsa-miR-30d-5p |
| hsa-miR-1273g-3p | hsa-miR-338-3p |
| hsa-miR-128 | hsa-miR-342-3p |
| hsa-miR-139-5p | hsa-miR-3665 |
| hsa-miR-145-5p | hsa-miR-3960 |
| has-miR-146a-5p | hsa-miR-4324 |
| hsa-miR-151a-5p | hsa-miR-4454 |
| hsa-miR-151b | hsa-miR-4516 |
| hsa-miR-16-5p | hsa-miR-451a |
| hsa-miR-181a-5p | hsa-miR-4787-5p |
| hsa-miR-181b-5p | hsa-miR-5001-5p |
| hsa-miR-181d | hsa-miR-5100 |
| hsa-miR-191-5p | hsa-miR-574-3p |
| hsa-miR-195-5p | hsa-miR-9-3p |
| hsa-miR-21-5p | hsa-miR-9-5p |
| hsa-miR-221-3p | hsa-miR-99a-5p |
| hsa-miR-222-3p | hsa-miR-99b-5p |
| hsa-miR-23a-3p |
Note that miRNAs are developmentally and temporally regulated and may display variable abundance in different cells or cell types; larger sample sets need to be analyzed to research these abundance patterns; at this point we cannot exclude the abundance and complexity of other enriched miRNA species. See also Burmistrova et al. (2007).