Table 4.

Summary of studies comparing limb sparing surgery with amputation.

Author	Timeframe that cohorts were treated	Conclusions regarding QoL	Conclusions regarding physical function
Eiser 2001 [17]	1977–1995	No significant difference	LSS superior over amputation
Refaat et al. 2002 [19]	1972–1987	No significant difference	No significant difference
Zahlten-Hinguranage et al. 2004 [21]	1980–2000	No significant difference	LSS superior over amputation
Pardasaney et al. 2006 [11]	—	No significant difference except for above knee amputation, which had inferior outcomes	No significant difference except for above knee amputation, which had inferior outcomes
Thijssens et al. 2006 [23]	1991–2003	No significant difference	LSS superior over amputation
Aksnes et al. 2008 [25]	1982–2000	No significant difference	LSS superior over amputation