Skip to main content
. Author manuscript; available in PMC: 2012 Sep 3.
Published in final edited form as: Mol Psychiatry. 2011 Apr 12;16(10):1024–1038. doi: 10.1038/mp.2011.36

Figure 5.

Figure 5

LeprDAT-Cre mice display enhanced VTA dopamine neuronal activity. Representative voltage traces from identified dopamine neurons demonstrate an irregular, single spike firing pattern of dopamine neurons in the VTA of a Leprflox/flox mouse (fWT, A & B) and a high burst-firing activity state in a LeprDAT-Cre mouse (C & D). (E) Average firing rate. (F) Burst firing (G) Firing rate distributions. (H) Burst-firing frequency distributions. Data are expressed as mean ± SEM. n = 7–10 mice, 64–72 neurons per group. (I–J) A representative electrode track throughout the VTA. *p < 0.05 compared to Leprflox/flox littermate controls. § representing a significant difference in proportions of high burst-firing cells and low burst-firing neurons, p < 0.05.