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Schematic representation of HIPK2 activation/inactivation. HIPK2 can be activated by: drugs, IR, UV, roscovitin. The so far known mechanisms of HIPK2 inhibition are: cytoplasmic localization, hypoxia, gene mutation, LOH, and HPV23 E6 or HMGA1 overexpression. HIPK2 inhibits the oncogenic Wnt/β-catenin and HIF-1 pathways. HIPK2 activates p53 for apoptotic function and inhibits the antiapoptotic CtBP, MDM2 and ΔNp63α proteins.
