Table 5.
The association between combined SNPs, hormone serum concentrations, ratios and SHBG concentration
| Genotype | Estradiol (pg/mL) | Estrone (pg/mL) | Testosterone (ng/mL) | Progesterone (ng/mL) | SHBG (nmol/L) | Free estradiol index | Free testosterone index | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||||
| Geometric mean 95%LL, UL |
p value | Geometric mean 95%LL, UL |
p value | Geometric mean 95%LL, UL |
p value | Geometric mean 95%LL, UL |
p value | Geometric mean 95%LL, UL |
p value | Geometric mean 95%LL, UL |
p value | Geometric mean 95%LL, UL |
p value | |
| AHR and AHRR | ||||||||||||||
| +/+ and +/+ | 97.75 86.39, 110.62 |
0.35 | 133.39 119.74, 148.59 |
0.15 | 0.43 0.40, 0.48 |
0.17 | 0.81 0.65, 1.01 |
0.50 |
63.41 57.91, 69.44 |
0.05 | 0.57 0.49, 0.65 |
0.26 |
2.37 2.06, 2.72 |
0.02 |
| +/+ and +/− or −/− | 100.15 92.11, 108.90 |
136.34 126.72, 146.68 |
0.48 0.45, 0.51 |
0.83 0.71, 0.96 |
56.06 52.72, 59.62 |
0.66 0.59, 0.72 |
2.95 2.69, 3.25 |
|||||||
| +/−,−/− and +/−, −/− | 87.80 74.97, 102.81 |
116.98 101.92, 134.28 |
0.49 0.43, 0.55 |
0.69 0.52, 0.91 |
54.09 48.17, 60.74 |
0.60 0.50, 0.72 |
3.12 2.61, 3.73 |
|||||||
| AHR and ARNT | ||||||||||||||
| +/+ and +/+ |
110.08 96.53, 125.52 |
0.05 |
149.34 133.14, 167.50 |
0.04 |
0.51 0.46, 0.56 |
0.04 | 0.88 0.69, 1.11 |
0.43 |
63.15 57.33, 69.56 |
0.04 | 0.64 0.55, 0.75 |
0.90 | 2.78 2.39, 3.23 |
0.12 |
| +/+ and +/− or −/− |
96.76 88.82, 105.41 |
129.74 120.39, 139.83 |
0.44 0.42, 0.47 |
0.81 0.69, 0.94 |
57.42 53.91, 61.16 |
0.62 0.56, 0.68 |
2.67 2.42, 2.94 |
|||||||
| +/−,−/− and +/−, −/− |
87.14 76.17, 99.69 |
122.00 08.46, 137.22 |
0.49 0.44, 0.54 |
0.70 0.55, 0.89 |
52.62 47.66, 58.10 |
0.61 0.52, 0.71 |
3.23 2.77, 3.77 |
|||||||
| AHR and CYP1B1 | ||||||||||||||
| +/+ and +/+ | 100.75 91.57, 110.85 |
0.49 | 135.00 124.19, 146.74 |
0.31 | 0.45 0.42, 0.49 |
0.49 | 0.85 0.71, 1.00 |
0.62 | 60.42 56.33, 64.82 |
0.17 | 0.61 0.55, 0.69 |
0.89 | 2.59 2.33, 2.89 |
0.13 |
| +/+ and +/− or −/− | 96.07 87.64, 105.32 |
132.56 122.35, 143.64 |
0.48 0.44, 0.51 |
0.75 0.64, 0.89 |
55.67 52.04, 59.56 |
0.63 0.57, 0.71 |
2.96 2.67, 3.29 |
|||||||
| +/−,−/− and +/−, −/− | 87.47 69.56, 110.01 |
114.08 93.39, 139.36 |
0.49 0.42, 0.58 |
0.79 0.53, 1.19 |
53.28 45.02, 63.06 |
0.60 0.46, 0.79 |
3.20 2.47, 4.16 |
|||||||
| CYP1B1 and CYP1B1 (rs1056836) | ||||||||||||||
| +/+ and +/+ | 99.47 87.57, 112.99 |
0.81 | 139.35 124.69, 155.73 |
0.39 | 0.49 0.45, 0.54 |
0.24 | 0.88 0.70, 1.10 |
0.51 | 56.42 51.40, 61.93 |
0.73 | 0.65 0.56, 0.75 |
0.58 | 3.03 2.62, 3.49 |
0.27 |
| +/+ and +/− or −/− | 95.00 86.32, 104.55 |
126.65 116.50, 137.70 |
0.45 0.42, 0.48 |
0.74 0.63, 0.88 |
58.80 54.82, 63.07 |
0.59 0.53, 0.66 |
2.63 2.36, 2.93 |
|||||||
| +/−,−/− and +/−, −/− | 98.67 87.95, 110.71 |
133.04 120.34, 147.09 |
0.47 0.43, 0.51 |
0.79 0.65, 0.97 |
56.80 52.22, 61.79 |
0.64 0.56, 0.73 |
2.88 2.53, 3.28 |
|||||||
95% LL,UL= 95% confidence limits; lower limit, upper limit
SHBG= sex hormone binding globulin
SNP= single nucleotide polymorphism