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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: J Mol Cell Cardiol. 2012 Jul 21;53(4):532–541. doi: 10.1016/j.yjmcc.2012.07.004

Figure 7. Transcriptional upregulation of ion channel subunits with activation of PI3Kα signaling is independent of Akt.

Figure 7

Channel subunit transcript expression levels were measured in individual LV samples from WT+Vehicle, icaPI3Kα+Vehicle and icaPI3Kα+TCN LV (n=6 in each group), normalized to Hprt in the same sample and to the mean value of the WT+Vehicle control LV samples. The expression levels of the transcripts encoding several K+ (A,B,C), as well as Na+ and Ca2+ (D), channel subunits were significantly (‡P<0.05, *P<0.001) higher in icaPI3Kα+Vehicle, compared with WT+Vehicle, LV. In addition, increased expression of the channel subunit transcripts with PI3Kα induction was unaffected by the addition of TCN and the resulting inhibition of Akt.