Table 2.
SNPs detected in the analysis of LDL and TG using a genome-wide significance of 0.05
| MTMM(p-valueα) |
EMMAX(p-valueα) |
|||||
|---|---|---|---|---|---|---|
| SNP | Position | full test | interaction | common | LDL | TG |
| CELSR2 region, chromosome 1 | ||||||
| rs611917 | 109616775 | 6.42 × 10-8 | 3.19 × 10-3 | 7.72 × 10-7 | 1.80 × 10-8 | 0.46 |
| rs646776 | 109620053 | 2.48 × 10-15 | 1.42 × 10-6 | 3.28 × 10-11 | 3.92 × 10-15 | 0.77 |
| APOB region, chromosome 2 | ||||||
| rs10198175 | 20997364 | 6.32 × 10-7 | 0.02 | 1.33 × 10-6 | 9.48 × 10-8 | 0.29 |
| rs3923037 | 21011755 | 6.39 × 10-9 | 0.13 | 2.64 × 10-9 | 2.72 × 10-7 | 7.17 × 10-7 |
| rs6728178 | 21047434 | 9.57 × 10-10 | 0.11 | 4.37 × 10-10 | 7.95 × 10-8 | 1.81 × 10-7 |
| rs6754295 | 21059688 | 1.31 × 10-9 | 0.14 | 4.97 × 10-10 | 7.10 × 10-8 | 4.12 × 10-7 |
| rs676210 | 21085029 | 2.43 × 10-9 | 0.04 | 2.56 × 10-9 | 7.23 × 10-7 | 9.21 × 10-8 |
| rs693 | 21085700 | 1.80 × 10-10 | 0.19 | 5.00 × 10-11 | 2.84 × 10-11 | 2.79 × 10-3 |
| rs673548 | 21091049 | 1.63 × 10-9 | 0.04 | 1.85 × 10-9 | 5.97 × 10-7 | 6.43 × 10-8 |
| rs1429974 | 21154275 | 4.85 × 10-7 | 0.02 | 1.06 × 10-6 | 7.69 × 10-8 | 0.24 |
| rs754524 | 21165046 | 5.30 × 10-8 | 0.02 | 1.39 × 10-7 | 7.83 × 10-9 | 0.17 |
| rs754523 | 21165196 | 4.51 × 10-7 | 0.02 | 1.01 × 10-6 | 7.15 × 10-8 | 0.24 |
| GCKR region, chromosome 2 | ||||||
| rs1260326 | 27584444 | 5.33 × 10-10 | 2.10 × 10-8 | 7.73 × 10-3 | 0.21 | 1.87 × 10-10 |
| rs780094 | 27594741 | 5.98 × 10-9 | 4.22 × 10-8 | 0.01 | 0.44 | 3.15 × 10-9 |
| LPL region, chromosome 8 | ||||||
| rs10096633 | 19875201 | 2.42 × 10-8 | 2.04 × 10-8 | 0.06 | 0.97 | 1.93 × 10-8 |
| FADS1 region, chromosome 11 | ||||||
| rs174537 | 61309256 | 1.60 × 10-9 | 9.02 × 10-9 | 0.01 | 6.82 × 10-6 | 3.81 × 10-3 |
| rs102275 | 61314379 | 8.79 × 10-10 | 6.20 × 10-9 | 4.86 × 10-3 | 4.13 × 10-6 | 3.82 × 10-3 |
| rs174546 | 61326406 | 5.52 × 10-10 | 3.83 × 10-9 | 4.88 × 10-3 | 3.69 × 10-6 | 3.12 × 10-3 |
| rs174556 | 61337211 | 2.56 × 10-9 | 4.43 × 10-8 | 1.93 × 10-3 | 2.03 × 10-6 | 0.01 |
| rs1535 | 61354548 | 2.08 × 10-9 | 1.35 × 10-8 | 0.01 | 6.04 × 10-6 | 4.96 × 10-3 |
| rs2072114 | 61361791 | 8.77 × 10-8 | 7.31 × 10-7 | 4.77 × 10-3 | 1.59 × 10-5 | 0.03 |
| LDLR region, chromosome 19 | ||||||
| rs11668477 | 11056030 | 3.16 × 10-8 | 0.15 | 1.18 × 10-8 | 3.89 × 10-9 | 0.02 |
| rs2228671 | 11071912 | 7.20 × 10-8 | 5.30 × 10-4 | 4.87 × 10-6 | 4.47 × 10-8 | 0.96 |
α
P-values below the Bonferroni-corrected 5% cut-off of 1.5 × 10-7 are highlighted in red.