(A-H) Phenotype of castrated and intact prostate. H&E of anterior prostate from intact or castrated Nkx3.1CE2/+ or Nkx3.1CE2/+; Ptenf/f mice. Mice at two months of age were induced with tamoxifen to form tumors; the ages indicated refer to the time following tumor induction. (I-L) Analyses of tumor regression following castration. Mice were induced to form tumors at 2 months of age (as above) and then castrated (or left intact) 4 months later. Shown are whole mount images of the urogenital regions including prostate (I, K), or H&E two weeks after castration (or mock surgery) (J, L).
Scale bars represent 100 mm.