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Gli2 is not required for AP autopod patterning when Gli3 is removed by ~E13. (A–F) Both digit number and AP autopod patterning are normal in all Gli3-E11.25 CKO limbs, with and without Gli2. (G–L) Controls demonstrating pre-axial partial digit 1 duplication (asterix), digit 4 p3 duplication (red arrow) and shortened zeugopods bones (black arrow) typical of Gli3+/− (G,H), Gli2+/−; Gli3+/− (I,J) and Gli2−/−; Gli3+/− (K,L) hindlimbs. See Figs. 1 and 2 for additional symbols.
