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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Eur J Med Chem. 2012 Jul 27;55C:325–334. doi: 10.1016/j.ejmech.2012.07.033

Scheme 1.

Scheme 1

Reagents and conditions: (a) n-BuLi, THF, 1,5-pentandiol ditosylate, 5 h, 80 °C; (b) Thd, K2CO3, DMF/acetone (1/1), 6 h, 50 °C; (c) TBAF, THF, 0.5 h, rt.