Table 4.
Stratified Multivariable model of factors associated with wound complications in patients undergoing breast cancer surgery
| 4a. Breast Conserving Surgery | ||||
|---|---|---|---|---|
| Factor | N (%) N=13791 | Adjusted Odds Ratio | 95% Confidence Interval | P value |
| Neoadjuvant Chemotherapy | 220 (1.6%) | 0.43 | 0.10–1.75 | 0.236 |
| Age | - | 0.99 | 0.98–1.00 | 0.032 |
| Race | ||||
| White | 10232 (74.2%) | 1.00 | Reference | |
| Black | 1320 (9.6%) | 1.22 | 0.84–1.78 | 0.363 |
| Other | 1047 (7.6%) | 1.02 | 0.64–1.63 | 0.739 |
| Smoker | 1849 (13.4%) | 1.12 | 0.78–1.61 | 0.536 |
| Partial/fully dependent | 98 (0.7%) | 3.16 | 1.25–7.95 | 0.015 |
| Overweight/obese | 9299 (67.4%) | 2.14 | 1.51–3.01 | <0.0001 |
| Diabetes mellitus | 1107 (8.0%) | 1.33 | 0.89–2.00 | 0.167 |
| Hypertension | 6202 (45.0%) | 1.14 | 0.85–1.53 | 0.398 |
| Axillary lymph node dissection* | 1663(12.1%) | 1.56 | 1.10–2.20 | 0.012 |
| 4b. Mastectomy | ||||
| Factor | N (%) N=21888 | Adjusted Odds Ratio | 95% Confidence Interval | P value |
| Neoadjuvant Chemotherapy | 1406 (6.4%) | 0.94 | 0.68–1.30 | 0.706 |
| Age | - | 1.00 | 0.99–1.00 | 0.242 |
| Race | ||||
| White | 15124 (69.1%) | 1.00 | Reference | |
| Black | 2620 (12.0%) | 0.74 | 0.59–0.94 | 0.254 |
| Other | 2317 (10.6%) | 0.74 | 0.56–0.97 | 0.285 |
| Smoker | 3368 (15.4%) | 1.68 | 1.39–2.02 | <0.0001 |
| Partial/fully dependent | 481 (2.2%) | 2.01 | 1.37–2.97 | 0.0004 |
| Overweight/obese | 14737 (67.3%) | 1.86 | 1.53–2.26 | <0.0001 |
| Diabetes mellitus | 2401 (11.0%) | 1.60 | 1.30–1.96 | <0.0001 |
| Hypertension | 10483 (47.9%) | 1.32 | 1.11–1.58 | 0.002 |
| Axillary lymph node dissection* | 15992 (73.1%) | 0.90 | 0.76–1.58 | 0.245 |
| 4c. Mastectomy with Immediate Reconstruction | ||||
| Factor | N (%) N=8854 | Adjusted Odds Ratio | 95% Confidence Interval | P value |
| Neoadjuvant Chemotherapy | 380 (4.3%) | 1.58 | 0.98–2.58 | 0.062 |
| Age | - | 1.01 | 1.00–1.02 | 0.209 |
| Race | ||||
| White | 6669 (75.3%) | 1.00 | Reference | |
| Black | 630 (7.1%) | 0.76 | 0.51–1.15 | 0.510 |
| Other | 734 (8.3%) | 0.78 | 0.51–1.21 | 0.652 |
| Smoker | 1220 (13.8%) | 1.60 | 1.21–2.14 | 0.001 |
| Partial/fully dependent | 25 (0.3%) | 0.90 | 0.12–6.94 | 0.921 |
| Overweight/obese | 4867 (55.0%) | 2.86 | 2.17–3.77 | <0.0001 |
| Diabetes mellitus | 329 (3.7%) | 1.86 | 1.22–2.84 | 0.004 |
| Hypertension | 2126 (24.0%) | 1.16 | 0.89–1.52 | 0.263 |
| Axillary lymph node dissection* | 4542 (51.3%) | 1.01 | 0.80–1.26 | 0.949 |
*
Analysis performed using sentinel lymph node biopsy as the reference