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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Microbes Infect. 2012 Apr 22;14(11):894–903. doi: 10.1016/j.micinf.2012.04.010

Figure 2. Schematic of the dominant HLA-A and HLA-B N-linked Glycans.

Figure 2

The MHCI molecules HLA-A and HLA-B carry unusually homogeneous N-glycan composition. Most glycoproteins tend to show high microheterogeneity at each N-glycosylation site, but for reasons that remain unclear, HLA-A and HLA-B molecules have been shown to contain one of these two structures most of the time. This is true for HLA-A and -B from cultured cells as well as in peripheral blood, demonstrating the universality of these findings. The functional consequences of this homogeneity is unknown.