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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Bone. 2012 Jun 29;51(4):787–794. doi: 10.1016/j.bone.2012.06.018

Figure 2. Effect of OVX and bisphosphonate treatment on trabecular bone in wild type (WT) and Gja1 conditional knockout (cKO) mice.

Figure 2

(A) Representative µCT reconstructions of femoral trabecular bone from 4-month-old WT and cKO mice that were either ovariectomised (OVX) or sham operated (sham), and treated with either vehicle (OVX+Veh), 20µg/kg risedronate (OVX+Ris), or 40µg/kg alendronate (OVX+Ale) for 4 weeks. (B) Trabecular bone volume (BV/TV); (C) Bone mineral content per tissue volume (BMC/TV); and (D) connectivity density determined at the end of the study by µCT in the different treatment groups (n=5). a, p< 0.05 vs WT; b, p< 0.05 vs Sham, 2-way ANOVA, and post-hoc multiple t-test (Holm-Sidak).