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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Bone. 2012 Jun 29;51(4):787–794. doi: 10.1016/j.bone.2012.06.018

Figure 3. Effect of OVX and bisphosphonate treatment on cortical bone in wild type (WT) and Gja1 conditional knockout (cKO) mice.

Figure 3

(A) Total tissue area; (B) marrow area; and (C) cortical thickness of femurs, determined by µCT, of 4-month-old WT and cKO mice (n=5) that were either ovariectomised (OVX) or sham operated (sham), and treated with either vehicle (OVX=Veh), 20µg/kg risedronate (OVX+Ris), or 40µg/kg alendronate (OVX+Ale) for 4 weeks. (D) Representative µCT cross-sections of femoral diaphysis of the different genotypes and treatment groups. a, p< 0.05 vs WT; b, p< 0.05 vs Sham; c, p<0.05 vs OVX+Veh; d, p< 0.05 vs OVX+Ris, 2-way ANOVA, and post-hoc multiple t-test (Holm-Sidak).