Figure 6. Effect of OVX and bisphosphonate treatment on bone mechanical properties in wild type (WT) and Gja1 conditional knockout (cKO) mice.
(A) Ultimate force and (B) bone stiffness of femurs, measured in a three-point bending protocol in the different genotypes and treated groups (n=4–7) (See Fig. 2 for abbreviations). (C) Cortical bone mineral density (BMD), measured by µCT in the different genotypes at the end of the study (n=5). a, p< 0.05 vs WT; b, p< 0.05 vs Sham; c, p<0.05 vs OVX+Veh; 2-way ANOVA, and post-hoc multiple t-test(Holm-Sidak).
