(A) Ultimate force and (B) bone stiffness of femurs, measured in a three-point bending protocol in the different genotypes and treated groups (n=4–7) (See Fig. 2 for abbreviations). (C) Cortical bone mineral density (BMD), measured by µCT in the different genotypes at the end of the study (n=5). a, p< 0.05 vs WT; b, p< 0.05 vs Sham; c, p<0.05 vs OVX+Veh; 2-way ANOVA, and post-hoc multiple t-test(Holm-Sidak).