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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Surgery. 2012 Jul 31;152(3):441–448. doi: 10.1016/j.surg.2012.05.040

FIGURE 4. Oncolytic activity of an oncolytic Ad construct in an orthotopic murine model of pancreatic cancer.

FIGURE 4

(A) Antitumor effects of oncolytic Ad agents were determined using a CFPAC-1 mouse xenograft model. When the tumor reached 10 mm3 in widest diameter, 5 × 109 i.f.u of Ad5/3-CXCR4-E1A (●), Ad5 wild-type (▼), Ad5-CMV-GFP (■) were injected intratumorally in a 30 μL volume. Control tumors were injected with an equal volume of PBS only (◆). The tumor volumes were calculated by multiplying the measured length × the measured width. Values represent the mean tumor size ± SEM. (B) Representative tumors shown in mice at 25 days after treatment.