Table 3.

Summary of change in disease status according to Expanded Disability Status Scale score

Change in disease status	Time period relative to baseline
	−12–0 months	0–6 months	6–12 months
Improvement	3.55	17.52	23.77
Stability	68.14	78.68	69.98
Worsening	28.31	3.8	6.25

Improvement defined as decrease ≥1 point on Expanded Disability Status Scale, stability as <1 point change, and worsening as increase ≥1 point over time. Only patients in treatment for 12 months included. The differences were statistically significant [p < 0.0001 (McNemar test)]