Table 3.
Mean response times and accuracies (±SD) on CogHealth tasks at baseline, and after 4, 8, and 12 weeks of Ax treatment
| Group/Task | Baseline |
4 weeks |
8 weeks |
12 weeks |
|||
|---|---|---|---|---|---|---|---|
| Mean ± SD | Mean ± SD | p (vs baseline) | Mean ± SD | p (vs baseline) | Mean ± SD | p (vs baseline) | |
| Placebo group (n = 31) | |||||||
| Response time (ms) | |||||||
| Simple reaction | 288.7 ± 59.1 | 271.5 ± 38.2 | 0.789 | 267.8 ± 40.6 | 0.345 | 265.0 ± 36.9 | 0.123 |
| Choice reaction | 467.5 ± 70.9 | 446.4 ± 53.1 | 0.506 | 453.1 ± 56.5 | 1.000 | 440.9 ± 52.8 | 0.124 |
| Working memory | 686.0 ± 148.9 | 647.7 ± 100.4 | 0.194 | 670.6 ± 151.5 | 1.000 | 644.6 ± 124.7 | 0.071† |
| Delayed recall | 909.7 ± 218.1 | 875.3 ± 217.8 | 1.000 | 887.8 ± 243.1 | 1.000 | 903.8 ± 270.1 | 1.000 |
| Divided attention | 413.0 ± 103.3 | 390.0 ± 75.2 | 0.597 | 379.6 ± 82.0 | 0.153 | 388.7 ± 73.9 | 0.397 |
| Accuracy (%) | |||||||
| Working memory | 95.1 ± 5.3 | 96.2 ± 3.8 | 1.000 | 95.2 ± 5.5 | 1.000 | 94.9 ± 8.3 | 1.000 |
| Delayed recall | 66.9 ± 10.3 | 68.8 ± 8.6 | 1.000 | 71.1 ± 10.4 | 0.355 | 69.2 ± 9.4 | 1.000 |
| AX low-dosage group (n = 29) | |||||||
| Response time (ms) | |||||||
| Simple reaction | 303.4 ± 81.7 | 284.3 ± 46.2 | 0.660 | 274.8 ± 39.4 | 0.077 | 285.0 ± 48.0 | 0.608 |
| Choice reaction | 468.0 ± 82.6 | 448.8 ± 60.4 | 0.558 | 440.2 ± 52.9 | 0.080 | 446.7 ± 44.0 | 0.393 |
| Working memory | 661.9 ± 120.2 | 651.4 ± 94.2 | 1.000 | 629.6 ± 96.4 | 0.352 | 641.6 ± 91.8 | 1.000 |
| Delayed recall | 912.2 ± 145.6 | 882.3 ± 139.5 | 1.000 | 844.4 ± 103.8 | 0.051† | 878.4 ± 131.4 | 1.000 |
| Divided attention | 428.8 ± 72.4 | 411.9 ± 85.7 | 1.000 | 406.7 ± 71.9 | 0.960 | 405.3 ± 81.6 | 0.483 |
| Accuracy (%) | |||||||
| Working memory | 94.1 ± 5.0 | 95.3 ± 4.4 | 1.000 | 96.4 ± 5.3 | 0.159 | 96.7 ± 3.7 | 0.186 |
| Delayed recall | 70.7 ± 6.7 | 72.4 ± 11.0 | 1.000 | 72.9 ± 8.8 | 1.000 | 71.0 ± 7.9 | 1.000 |
| AX high-dosage group (n = 29) | |||||||
| Response time (ms) | |||||||
| Simple reaction | 302.9 ± 71.2 | 292.2 ± 49.7 | 1.000 | 284.5 ± 56.7 | 0.626 | 280.6 ± 47.3 | 0.242 |
| Choice reaction | 480.1 ± 77.5 | 454.7 ± 64.1 | 0.207 | 453.1 ± 67.2 | 0.104 | 451.1 ± 56.7 | 0.083† |
| Working memory | 655.9 ± 136.5 | 638.6 ± 130.2 | 1.000 | 624.5 ± 132.1 | 0.319 | 609.2 ± 123.5 | 0.044* |
| Delayed recall | 880.1 ± 189.4 | 843.9 ± 182.8 | 0.852 | 829.4 ± 209.8 | 0.302 | 818.3 ± 195.9 | 0.097† |
| Divided attention | 419.4 ± 79.6 | 415.4 ± 104.9 | 1.000 | 392.3 ± 86.9 | 0.483 | 385.3 ± 72.5 | 0.074† |
| Accuracy (%) | |||||||
| Working memory | 95.4 ± 5.8 | 93.8 ± 6.6 | 0.433 | 95.4 ± 5.5 | 1.000 | 95.6 ± 7.4 | 1.000 |
| Delayed recall | 67.3 ± 11.8 | 71.3 ± 9.0 | 0.361 | 71.5 ± 7.3 | 0.320 | 72.9 ± 7.5 | 0.028* |
Dropouts were excluded from the data analysys. †p<0.1, *p<0.05, **p<0.01 (vs baseline). Data were analyzed by one-way repeated measure ANOVA, adjusted for age and sex. Multiple comparisons of 4, 8, and 12 weeks with baseline were performed using Bonferroni correction.